The NeuroStar TMS Therapy® system is the first and only non-systemic and non-invasive TMS system cleared by the U.S. Food and Drug Administration (FDA) for patients with major depression who have not benefited from prior antidepressant treatment.* The NeuroStar® TMS system uses a highly focused, pulsed magnetic field to stimulate function in targeted brain regions. NeuroStar TMS Therapy is: Non-invasive, meaning that it does not involve surgery. It does not require any anesthesia or sedation, and the patient remains awake and alert during the treatment. Non-systemic, meaning that it is not taken by mouth and does not circulate in the bloodstream throughout the body. What is TMS Therapy?